AdipoUpX™ Human IKBKB MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human IKBKB MMLV Particle (Overexpression) is a stable integration tool for the specific and efficient overexpression of the human IKBKB (IKK-beta) gene. This kinase is a master regulator of the NF-κB pathway, providing a crucial tool for studying the inflammatory link between obesity and Type 2 Diabetes. By integrating stably into the dividing host cell genome, it facilitates the rapid validation of pro-inflammatory signaling in metabolic tissues. Product quality is ensured by rigorous purification and comprehensive QC screening against various contaminants.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: IKBKB

Full Name: Inhibitor of nuclear factor kappa B kinase subunit beta

Gene Symbol: IKK2; IKKB; IKK-2; IMD15; IMD15A; IMD15B; NFKBIKB; IKK-beta

Gene ID: 3551

RefSeq ID-1: NP_001177649.1

RefSeq ID-2: NM_001190720.2

Summary: IKBKB encodes a catalytic component of the IκB kinase complex that activates NF-κB signaling by phosphorylating inhibitory proteins. NF-κB signaling integrates inflammatory and metabolic cues, and persistent activation of IKBKB is associated with chronic inflammation and insulin resistance in obesity. Both protein-coding and noncoding transcript variants have been described.

AdipoUpX™ Human IKBKB MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

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