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Vitamin B12 test kit

AdipoUpX™ Human PCSK1 MMLV Particle (Overexpression)

Cat. No.: V1225XX602
Species: Human
Target Gene: PCSK1
Vector System: MMLV Retrovirus
Modulation Type: Overexpression
AdipoUpX™ Human PCSK1 MMLV Particle (Overexpression)
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Product Overview

Description: AdipoUpX™ Human PCSK1 MMLV Particle (Overexpression) is a powerful gene delivery tool designed for the stable overexpression of the human PCSK1 gene. This prohormone convertase is vital for the processing of key metabolic peptides like proinsulin and POMC. Because the MMLV vector stably integrates into the genome of dividing cells, it is an ideal tool for establishing permanent cell lines for neuroendocrine research. Every viral product undergoes comprehensive quality control screening to ensure high efficacy and safety.
Production Cell Line: HEK293T
Promoter: Ubi; CMV; EF1a; Others
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.
Sterility Test: The final viral preparation was confirmed sterile after testing.
Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.
Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.
Storage: The product must be immediately transferred to -80 °C storage upon its arrival.
Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.
Shipping Condition: Our MMLV retroviral products are shipped using dry ice.
Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: PCSK1
Full Name: Proprotein convertase subtilisin/kexin type 1
Gene Symbol: PC1; PC3; NEC1; SPC3; PC1/3; BMIQ12
Gene ID: 5122
RefSeq ID-1: NP_000430.3
RefSeq ID-2: NM_000439.4
Summary: PCSK1 encodes a protease of the subtilisin-like proprotein convertase family that is essential for the maturation of peptide hormones and neuropeptides. The protein is synthesized as an inactive precursor and undergoes stepwise autocatalytic processing, first within the endoplasmic reticulum and later in secretory compartments, where enzymatic activity is fully established. PCSK1 is primarily expressed in the neuroendocrine system and brain and selectively cleaves substrates at basic amino acid motifs. Genetic defects in PCSK1 are strongly associated with obesity predisposition and proprotein convertase 1/3 deficiency. Multiple isoforms of PCSK1 arise from alternative splicing.

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