AdipoUpX™ Human GDF15 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human GDF15 Lentiviral Particle (Overexpression) is a powerful gene delivery tool specifically designed for the stable overexpression of the human GDF15 gene. As a stress-induced cytokine that suppresses appetite via the hindbrain, genome integration allows for the establishment of stable cell lines to study its systemic anti-obesity effects. All particles undergo rigorous quality control screening to ensure experimental reliability. Our customizable platform supports the flexible inclusion of reporter genes and various promoters for precise multifunctional tracking.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: GDF15

Full Name: Growth differentiation factor 15

Gene Symbol: HG; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15

Gene ID: 9518

RefSeq ID-1: NP_004855.2

RefSeq ID-2: NM_004864.4

Summary: GDF15 encodes a stress-induced, secreted cytokine belonging to the TGF-β superfamily. The protein acts as a systemic signal in response to cellular injury, inflammation, and metabolic stress. Elevated GDF15 levels have been associated with appetite suppression and weight regulation in pathological and metabolic conditions.

AdipoUpX™ Human GDF15 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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