AdipoUpX™ Human BDNF Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human BDNF Lentiviral Particle (Overexpression) is a ready-to-use, high-titer vector particle professionally engineered for the stable overexpression of the human BDNF gene. BDNF is a master regulator of appetite control and neuronal plasticity; this stable integration tool allows for the creation of reliable cell lines for neuro-metabolic research. To ensure experimental safety and efficacy, all products undergo comprehensive quality control, including titer and mycoplasma detection, with support for flexible reporter gene customization.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: BDNF

Full Name: Brain derived neurotrophic factor

Gene Symbol: ANON2; BULN2

Gene ID: 627

RefSeq ID-1: NP_001137277.1

RefSeq ID-2: NM_001143805.1

Summary: BDNF is a pivotal protein belonging to the nerve growth factor family. Synthesized as a preproprotein, it undergoes necessary proteolytic processing to yield the mature, bioactive form. In the adult brain, BDNF is crucial for promoting neuronal survival, plasticity, and differentiation by binding to its cognate receptor (TrkB). This neurotrophin plays a key modulatory role in the stress response and the underlying biology of mood disorders like depression. Pathologically, reduced BDNF expression is commonly observed in patients suffering from severe neurodegenerative conditions, including Alzheimer's, Parkinson's, and Huntington's disease.

AdipoUpX™ Human BDNF Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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