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AdipoUpX™ Human BBS1 AAV Particle (Overexpression)
Cat. No.:
V1225XX230
Species:
Human
Target Gene:
BBS1
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX230-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX230-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX230-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX230-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX230-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX230-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX230-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX230-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX230-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX230-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human BBS1 AAV Particle (Overexpression) is engineered for functional validation and signaling studies, confirming efficient expression of the human BBS1 gene. As a core component of the BBSome, it is critical for systematic investigation into ciliary trafficking and the pathogenesis of Bardet-Biedl Syndrome. Clients can freely select from multiple AAV serotypes and fluorescent reporter genes for precise targeted delivery. Comprehensive quality control is performed on all products to ensure experimental reproducibility and safety.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
BBS1
Full Name:
Bardet-Biedl syndrome 1
Gene Symbol:
BBS2L2
Gene ID:
582
RefSeq ID-1:
NP_078925.3
RefSeq ID-2:
NM_024649.4
Summary:
BBS1 encodes a subunit of the BBSome complex, a molecular machine vital for the assembly, movement, and functional maintenance of primary cilia. Mutations in BBS1 are the most frequent cause of Bardet-Biedl Syndrome (BBS Type 1), a complex, recessive ciliopathy. BBS highlights the crucial role of ciliary signaling in development and metabolism, presenting with a severe, multisystem phenotype including retinal degeneration, learning disabilities, renal anomalies, and profound truncal obesity, demonstrating that defective ciliary function is a major cause of monogenic human obesity.
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