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AdipoUpX™ Human ATF6 AAV Particle (Overexpression)
Cat. No.:
V1225XX381
Species:
Human
Target Gene:
ATF6
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX381-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX381-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX381-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX381-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX381-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX381-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX381-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX381-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX381-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX381-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human ATF6 AAV Particle (Overexpression) is a ready-to-use gene delivery tool that has undergone rigorous quality control to ensure stable expression of the human ATF6 gene. As a critical sensor of ER stress, it is a powerful asset for researching the unfolded protein response and its contribution to insulin resistance and cholesterol dysregulation. Our AAV platform offers the benefit of high customization, allowing clients to select from multiple AAV serotypes and promoters. Comprehensive QC, including titer, sterility, and mycoplasma testing, is performed to ensure experimental reproducibility and safety.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
ATF6
Full Name:
Activating transcription factor 6
Gene Symbol:
ACHM7; ATF6A; ATP6alpha
Gene ID:
22926
RefSeq ID-1:
NP_031374.2
RefSeq ID-2:
NM_007348.4
Summary:
ATF6 encodes an endoplasmic reticulum–associated transcription factor that plays a central role in activating the unfolded protein response (UPR) under conditions of ER stress. Unlike conventional transcription factors, ATF6 is initially synthesized as a transmembrane protein localized to the ER membrane, where it serves as a stress sensor. Upon ER stress, ATF6 undergoes regulated proteolytic cleavage, releasing an active fragment that translocates to the nucleus and binds ER stress response elements (ERSEs) in the promoters of genes encoding ER chaperones. Persistent ER stress is a hallmark of obesity-related metabolic tissues, including adipose tissue and liver, linking ATF6 signaling to insulin resistance and dyslipidemia. Polymorphisms in ATF6 have shown variable associations with diabetes across populations, while other variants correlate with elevated plasma cholesterol. ATF6 has also been identified as a survival factor in quiescent squamous carcinoma cells and is being explored as a therapeutic target in cystic fibrosis.
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