Rat insulin receptor substrate 1 (IRS-1) ELISA kit (0.312-20 ng/mL)

Cat. No.: 0126WXX-702

Assay Type: Quantitative sandwich ELISA

Target Species: Rat

Assay Target: IRS-1

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Rat insulin receptor substrate 1 (IRS-1) ELISA kit (0.312-20 ng/mL)

INQUIRY Datasheet MSDS

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Product Overview

Description: Rat insulin receptor substrate 1 (IRS-1) ELISA kit (0.312-20 ng/mL) is an ELISA-based in vitro research tool designed specifically for the quantitative detection of IRS-1 in rat samples with a range of 0.312-20 ng/mL and a minimum detectable dose (sensitivity) of 0.174 ng/mL. The kit is highly sensitive and easy to use.

Assay Principle: The ELISA analytical biochemical technique is based on IRS-1 antibody-IRS-1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IRS-1 antigen targets in samples.

Background: IRS-1 is a key adaptor protein that plays a central role in insulin signaling. When insulin binds to its receptor on the cell surface, the receptor is activated and phosphorylates tyrosine residues on IRS-1. This process transforms IRS-1 into a signaling “relay station,” enabling it to bind with multiple downstream signaling proteins such as phosphoinositide 3-kinase (PI3K). IRS-1 transmits insulin signals from the cell membrane into the cell interior, thereby initiating a series of vital biological responses, including promoting glucose transport and glycogen synthesis. Studying the function and defects of IRS-1 is crucial for understanding the pathological processes underlying obesity.

Synonyms: IRS1

Applications: Rat insulin receptor substrate 1 (IRS-1) ELISA kit (0.312-20 ng/mL) is used to quantify IRS-1 in serum, plasma, whole blood, tissue, saliva, urine, feces, and other fluids of rat, providing data to support research in a wide range of areas, including endocrinology, obesity, etc.

Research Area: Endocrinology; Obesity