Inquiry
Products
Online Inquiry

Please note that we are not a pharmacy or clinic, so we are unable to see patients and do not offer diagnostic and treatment services for individuals.

Vitamin B12 test kit

LipoKnoxa™ Human TNMD shRNA AAV Particle (Silencing)

Cat. No.: V0126XX416
Species: Human
Target Gene: TNMD
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human TNMD shRNA AAV Particle (Silencing)
INQUIRY Datasheet MSDS
SPECIFIC INQUIRY
Fluorescent Reporters:
Titer:
Size:
Add to basket
Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX416-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GAGAGAGGTTATTGTTGTATT CDS Inquiry
V0126XX416-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CGCGTCTGTGAACCTTTACTA CDS Inquiry
V0126XX416-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GAGGAAATAGATGAGAATGAA CDS Inquiry
V0126XX416-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GAGAGAGGTTATTGTTGTATT CDS Inquiry
V0126XX416-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CGCGTCTGTGAACCTTTACTA CDS Inquiry
V0126XX416-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GAGGAAATAGATGAGAATGAA CDS Inquiry
V0126XX416-7 AAV3 Lung; Liver; Smooth muscle GAGAGAGGTTATTGTTGTATT CDS Inquiry
V0126XX416-8 AAV3 Lung; Liver; Smooth muscle CGCGTCTGTGAACCTTTACTA CDS Inquiry
V0126XX416-9 AAV3 Lung; Liver; Smooth muscle GAGGAAATAGATGAGAATGAA CDS Inquiry
V0126XX416-10 AAV4 CNS; Retina; Heart; Lung; Kidney GAGAGAGGTTATTGTTGTATT CDS Inquiry
V0126XX416-11 AAV4 CNS; Retina; Heart; Lung; Kidney CGCGTCTGTGAACCTTTACTA CDS Inquiry
V0126XX416-12 AAV4 CNS; Retina; Heart; Lung; Kidney GAGGAAATAGATGAGAATGAA CDS Inquiry
V0126XX416-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GAGAGAGGTTATTGTTGTATT CDS Inquiry
V0126XX416-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CGCGTCTGTGAACCTTTACTA CDS Inquiry
V0126XX416-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GAGGAAATAGATGAGAATGAA CDS Inquiry
V0126XX416-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GAGAGAGGTTATTGTTGTATT CDS Inquiry
V0126XX416-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CGCGTCTGTGAACCTTTACTA CDS Inquiry
V0126XX416-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GAGGAAATAGATGAGAATGAA CDS Inquiry
V0126XX416-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GAGAGAGGTTATTGTTGTATT CDS Inquiry
V0126XX416-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CGCGTCTGTGAACCTTTACTA CDS Inquiry
V0126XX416-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GAGGAAATAGATGAGAATGAA CDS Inquiry
V0126XX416-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GAGAGAGGTTATTGTTGTATT CDS Inquiry
V0126XX416-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CGCGTCTGTGAACCTTTACTA CDS Inquiry
V0126XX416-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GAGGAAATAGATGAGAATGAA CDS Inquiry
V0126XX416-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GAGAGAGGTTATTGTTGTATT CDS Inquiry
V0126XX416-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CGCGTCTGTGAACCTTTACTA CDS Inquiry
V0126XX416-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GAGGAAATAGATGAGAATGAA CDS Inquiry
V0126XX416-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human TNMD shRNA AAV Particle (Silencing) targets tenomodulin, an adipokine associated with adipose tissue health and glucose metabolism. Engineered via our dual-strategy platform (U6 and miR30 systems), this tool enables researchers to investigate the maintenance of healthy fat depots. Multiple AAV serotypes are available to ensure optimal delivery. Every batch undergoes comprehensive quality control, covering functional titer, sequence verification, and the total absence of pathogens.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: TNMD
Full Name: Tenomodulin
Gene Symbol: TEM; CHM1L; BRICD4
Gene ID: 64102
RefSeq ID-1: NP_071427.2
RefSeq ID-2: NM_022144.3
Summary: TNMD encodes a protein structurally related to chondromodulin-I, a cartilage-associated glycoprotein that stimulates chondrocyte growth and inhibits endothelial tube formation. TNMD functions as an angiogenesis inhibitor and has been linked to the regulation of tissue vascularization. Genetic variants in TNMD are associated with central obesity, type 2 diabetes risk, and circulating immune mediator levels in a body size–dependent manner. The gene has also been proposed as a candidate for age-related macular degeneration.

Related Products

Inquiry
0
Inquiry Basket

Recognizing the multifaceted nature of obesity, we leverage our expertise in preclinical research to provide tailored solutions that address the unique challenges faced by our partners in the biotechnology and pharmaceutical industries.

By Molecule Type

By Products

By Services

Contact Us

Copyright © Protheragen. All rights reserves.