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Vitamin B12 test kit

LipoKnoxa™ Human IL13 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX405
Species: Human
Target Gene: IL13
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human IL13 shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX405-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle ACTTCGAAAGCATCATTATTT 3' UTR Inquiry
V0126XX405-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle ATTGAAGTTGCAGATTCATTT 3' UTR Inquiry
V0126XX405-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CCTGCTCTTACATTTAAAGAA CDS Inquiry
V0126XX405-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle ACTTCGAAAGCATCATTATTT 3' UTR Inquiry
V0126XX405-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle ATTGAAGTTGCAGATTCATTT 3' UTR Inquiry
V0126XX405-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CCTGCTCTTACATTTAAAGAA CDS Inquiry
V0126XX405-7 AAV3 Lung; Liver; Smooth muscle ACTTCGAAAGCATCATTATTT 3' UTR Inquiry
V0126XX405-8 AAV3 Lung; Liver; Smooth muscle ATTGAAGTTGCAGATTCATTT 3' UTR Inquiry
V0126XX405-9 AAV3 Lung; Liver; Smooth muscle CCTGCTCTTACATTTAAAGAA CDS Inquiry
V0126XX405-10 AAV4 CNS; Retina; Heart; Lung; Kidney ACTTCGAAAGCATCATTATTT 3' UTR Inquiry
V0126XX405-11 AAV4 CNS; Retina; Heart; Lung; Kidney ATTGAAGTTGCAGATTCATTT 3' UTR Inquiry
V0126XX405-12 AAV4 CNS; Retina; Heart; Lung; Kidney CCTGCTCTTACATTTAAAGAA CDS Inquiry
V0126XX405-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle ACTTCGAAAGCATCATTATTT 3' UTR Inquiry
V0126XX405-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle ATTGAAGTTGCAGATTCATTT 3' UTR Inquiry
V0126XX405-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CCTGCTCTTACATTTAAAGAA CDS Inquiry
V0126XX405-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle ACTTCGAAAGCATCATTATTT 3' UTR Inquiry
V0126XX405-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle ATTGAAGTTGCAGATTCATTT 3' UTR Inquiry
V0126XX405-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CCTGCTCTTACATTTAAAGAA CDS Inquiry
V0126XX405-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle ACTTCGAAAGCATCATTATTT 3' UTR Inquiry
V0126XX405-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle ATTGAAGTTGCAGATTCATTT 3' UTR Inquiry
V0126XX405-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CCTGCTCTTACATTTAAAGAA CDS Inquiry
V0126XX405-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle ACTTCGAAAGCATCATTATTT 3' UTR Inquiry
V0126XX405-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle ATTGAAGTTGCAGATTCATTT 3' UTR Inquiry
V0126XX405-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CCTGCTCTTACATTTAAAGAA CDS Inquiry
V0126XX405-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle ACTTCGAAAGCATCATTATTT 3' UTR Inquiry
V0126XX405-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle ATTGAAGTTGCAGATTCATTT 3' UTR Inquiry
V0126XX405-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CCTGCTCTTACATTTAAAGAA CDS Inquiry
V0126XX405-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human IL13 shRNA AAV Particle (Silencing) targets interleukin-13, a cytokine involved in type 2 immunity and metabolic regulation in the liver and fat. By utilizing our dual-strategy platform (U6 and miR30 systems), researchers can explore its role in alternative macrophage activation and insulin sensitivity. Multiple AAV serotypes are available for selection. Every batch is subjected to rigorous QC, including functional titer and sterility testing, to guarantee the highest level of biosafety.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: IL13
Full Name: Interleukin 13
Gene Symbol: P600; IL-13
Gene ID: 3596
RefSeq ID-1: NP_002179.2
RefSeq ID-2: NM_002188.2
Summary: IL13 encodes a Th2-derived immunoregulatory cytokine that plays important roles in B-cell maturation and differentiation. It enhances CD23 and MHC class II expression and promotes immunoglobulin E (IgE) class switching in B cells. IL13 also suppresses macrophage activation, thereby reducing the production of pro-inflammatory cytokines and chemokines. While IL13 is a key mediator in allergen-induced asthma through IgE-independent mechanisms, it also contributes to immune regulation within adipose tissue. Altered IL13 signaling may influence obesity-associated inflammation and metabolic dysfunction. IL13 is located within a cytokine gene cluster on chromosome 5q, in close proximity to IL4.

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