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Vitamin B12 test kit

LipoKnoxa™ Human STAT3 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX319
Species: Human
Target Gene: STAT3
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human STAT3 shRNA AAV Particle (Silencing)
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX319-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CTCAGAGGATCCCGGAAATTT CDS Inquiry
V0126XX319-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GGCGTCCAGTTCACTACTAAA CDS Inquiry
V0126XX319-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CATCTGAAACTACTAACTTTG 3' UTR Inquiry
V0126XX319-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CTCAGAGGATCCCGGAAATTT CDS Inquiry
V0126XX319-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GGCGTCCAGTTCACTACTAAA CDS Inquiry
V0126XX319-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CATCTGAAACTACTAACTTTG 3' UTR Inquiry
V0126XX319-7 AAV3 Lung; Liver; Smooth muscle CTCAGAGGATCCCGGAAATTT CDS Inquiry
V0126XX319-8 AAV3 Lung; Liver; Smooth muscle GGCGTCCAGTTCACTACTAAA CDS Inquiry
V0126XX319-9 AAV3 Lung; Liver; Smooth muscle CATCTGAAACTACTAACTTTG 3' UTR Inquiry
V0126XX319-10 AAV4 CNS; Retina; Heart; Lung; Kidney CTCAGAGGATCCCGGAAATTT CDS Inquiry
V0126XX319-11 AAV4 CNS; Retina; Heart; Lung; Kidney GGCGTCCAGTTCACTACTAAA CDS Inquiry
V0126XX319-12 AAV4 CNS; Retina; Heart; Lung; Kidney CATCTGAAACTACTAACTTTG 3' UTR Inquiry
V0126XX319-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CTCAGAGGATCCCGGAAATTT CDS Inquiry
V0126XX319-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GGCGTCCAGTTCACTACTAAA CDS Inquiry
V0126XX319-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CATCTGAAACTACTAACTTTG 3' UTR Inquiry
V0126XX319-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CTCAGAGGATCCCGGAAATTT CDS Inquiry
V0126XX319-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GGCGTCCAGTTCACTACTAAA CDS Inquiry
V0126XX319-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CATCTGAAACTACTAACTTTG 3' UTR Inquiry
V0126XX319-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CTCAGAGGATCCCGGAAATTT CDS Inquiry
V0126XX319-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GGCGTCCAGTTCACTACTAAA CDS Inquiry
V0126XX319-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CATCTGAAACTACTAACTTTG 3' UTR Inquiry
V0126XX319-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CTCAGAGGATCCCGGAAATTT CDS Inquiry
V0126XX319-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GGCGTCCAGTTCACTACTAAA CDS Inquiry
V0126XX319-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CATCTGAAACTACTAACTTTG 3' UTR Inquiry
V0126XX319-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CTCAGAGGATCCCGGAAATTT CDS Inquiry
V0126XX319-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GGCGTCCAGTTCACTACTAAA CDS Inquiry
V0126XX319-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CATCTGAAACTACTAACTTTG 3' UTR Inquiry
V0126XX319-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human STAT3 shRNA AAV Particle (Silencing) targets STAT3, a downstream mediator of leptin signaling in the hypothalamus. By utilizing our dual-strategy platform (U6 and miR30 systems), researchers can investigate the genetic basis of leptin resistance. Our platform offers multiple AAV serotypes to ensure high-efficiency transduction in specific brain nuclei. Each preparation is verified via total QC validation—including functional titer and sterility testing.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: STAT3
Full Name: Signal transducer and activator of transcription 3
Gene Symbol: APRF; HIES; ADMIO; ADMIO1
Gene ID: 6774
RefSeq ID-1: NP_001356441.1
RefSeq ID-2: NM_001369512.1
Summary: STAT3 encodes a signal transducer and transcriptional activator that responds to cytokines and growth factors through phosphorylation-dependent activation. Once activated, STAT3 dimerizes and translocates to the nucleus to regulate genes involved in cell growth, apoptosis, and immune responses. In the central nervous system and peripheral tissues, STAT3 signaling is also involved in appetite control, energy expenditure, and metabolic regulation. Mutations in STAT3 cause immune dysregulation syndromes and can affect metabolic homeostasis.

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