Human insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) ELISA kit

Cat. No.: 0126WXX-464

Assay Type: Quantitative ELISA

Target Species: Human

Assay Target: IGF2BP2

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Human insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) ELISA kit

INQUIRY Datasheet MSDS

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Product Overview

Description: Human insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) ELISA kit is an ELISA-based in vitro research tool designed specifically for the quantitative detection of IGF2BP2 in human samples with a range of 125-8000 pg/mL and a minimum detectable dose (sensitivity) of 31.25 pg/mL. The kit is highly sensitive and easy to use.

Assay Principle: The microtiter plate provided in this kit is pre-immobilized with an antibody specific to IGF2BP2. Standards or samples are added to the wells along with a biotin-conjugated antibody and avidin-HRP. Following incubation, a TMB substrate solution is introduced. Color development occurs only in wells containing the IGF2BP2 sandwich complex. The enzymatic reaction is terminated with a sulphuric acid solution, and the color change is measured spectrophotometrically at 450 nm ± 2 nm. The concentration of IGF2BP2 in the samples is determined by comparing the O.D. values to the established standard curve.

Background: IGF2BP2 is an RNA-binding protein that regulates the stability and translation of various mRNAs. Specific variants in its gene are significantly associated with increased risk of type 2 diabetes and obesity, indicating IGF2BP2's crucial role in insulin signaling and metabolic regulation.

Synonyms: IGF2 mRNA-binding protein 2; IMP-2; Hepatocellular carcinoma autoantigen p62; IGF-II mRNA-binding protein 2; VICKZ family member 2

Applications: Human insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) ELISA kit is used to quantify IGF2BP2 in serum, plasma, and tissue homogenates, and cell lysates of human, providing data to support research in a wide range of areas, including metabolism, obesity, and others.

Research Area: Metabolism; Obesity

Specification

Sample Type: Serum; Plasma; Tissue homogenates; Cell lysates

Detection Range: 125-8000 pg/mL

Sensitivity: 31.25 pg/mL

Precision (Intra-assay): CV<8%

Precision (Inter-assay): CV<10%

Cross-reactivity: No significant cross-reactivity or interference was observed.

Storage: Store at 2-8°C.

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