Canine tumor necrosis factor soluble receptor II (TNFSR-II) ELISA kit-Quantitative sandwich

Cat. No.: 0126WXX-1953

Assay Type: Quantitative sandwich ELISA

Target Species: Canine

Assay Target: TNFSR-II

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Canine tumor necrosis factor soluble receptor II (TNFSR-II) ELISA kit-Quantitative sandwich

INQUIRY Datasheet MSDS

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Product Overview

Description: Canine tumor necrosis factor soluble receptor II (TNFSR-II) ELISA kit-Quantitative sandwich is an ELISA-based in vitro research tool designed specifically for the quantitative detection of TNFSR-II in canine samples with a range of 0.25-8 ng/mL and a minimum detectable dose (sensitivity) of 0.1 ng/mL. The kit is highly sensitive and easy to use.

Assay Principle: The ELISA analytical biochemical technique is based on TNFSR-II antibody-TNFSR-II antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TNFSR-II antigen targets in samples.

Background: TNFSR-II is the free form released into the bloodstream following proteolytic cleavage of the membrane-bound TNF-RII receptor (TNFRSF1B). TNFSR-II primarily functions as a decoy receptor, capable of binding circulating tumor necrosis factor TNF-α to neutralize its activity and reduce its binding to membrane-bound receptors, thereby negatively regulating systemic inflammation. In obesity research, serum TNFSR-II concentration is a recognized and reliable biomarker of chronic low-grade inflammation and endothelial dysfunction. Elevated TNFSR-II levels are significantly associated with central obesity, insulin resistance, metabolic syndrome, and subsequent cardiovascular disease risk. Consequently, it is frequently used to assess inflammatory burden and disease progression in obese patients.

Synonyms: TNFsr-II; sTNFR2

Applications: Canine tumor necrosis factor soluble receptor II (TNFSR-II) ELISA kit-Quantitative sandwich is used to quantify TNFSR-II in canine samples, providing data to support research in a wide range of areas, including inflammation, metabolism, obesity, and others.

Research Area: Inflammation; Metabolism; Obesity

Specification

Sample Type: Canine samples

Detection Range: 0.25-8 ng/mL

Sensitivity: 0.1 ng/mL

Precision (Intra-assay): CV<15%

Precision (Inter-assay): CV<15%

Cross-reactivity: No significant cross-reactivity or interference was observed.

Storage: Store at 2-8°C.

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