AdipoUpX™ Human SREBF2 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human SREBF2 Lentiviral Particle (Overexpression) is a ready-to-use, high-titer vector particle designed for the efficient and stable overexpression of the human SREBF2 gene. As the master transcription factor for cholesterol biosynthesis, its stable genomic integration provides a reliable platform for researching the molecular response to dietary lipids and statins. To ensure experimental reproducibility, the product undergoes comprehensive quality control, including titer and mycoplasma testing. Researchers can flexibly choose from various promoters for precise targeted expression.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: SREBF2

Full Name: Sterol regulatory element binding transcription factor 2

Gene Symbol: SREBP2; bHLHd2; SREBP-2

Gene ID: 6721

RefSeq ID-1: NP_004590.2

RefSeq ID-2: NM_004599.3

Summary: SREBF2 is the master "cholesterol thermostat" of the cell. This transcription factor senses when cellular cholesterol levels are low and subsequently activates the genes required for cholesterol synthesis and uptake. By maintaining this precise balance, SREBF2 ensures that cells have enough cholesterol for membranes while preventing toxic excess.

AdipoUpX™ Human SREBF2 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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