AdipoUpX™ Human KCNJ5 MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human KCNJ5 MSCV Particle (Overexpression) is a stable gene delivery vector for the human KCNJ5 gene, encoding an inwardly rectifying potassium channel. KCNJ5 influences membrane potential and hormone secretion pathways that indirectly affect metabolic regulation and adiposity. The MSCV system supports long-term expression in stem cells and other mammalian cell lines. All products are validated by rigorous quality control, including titer, sterility, and mycoplasma testing.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: KCNJ5

Full Name: Potassium inwardly rectifying channel subfamily J member 5

Gene Symbol: CIR; GIRK4; KATP1; LQT13; KIR3.4

Gene ID: 3762

RefSeq ID-1: NP_000881.3

RefSeq ID-2: NM_000890.3

Summary: KCNJ5 produces an inward-rectifier potassium channel subunit that is regulated by G-proteins. This channel helps maintain the electrical gradient of the cell by allowing potassium to flow inward. Mutations in KCNJ5 are strongly associated with aldosterone-producing adenomas, which disrupt the hormonal balance of minerals and can impact blood pressure and metabolic stability.

AdipoUpX™ Human KCNJ5 MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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