AdipoUpX™ Human IL6 MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human IL6 MMLV Particle (Overexpression) is a high-titer MMLV particle designed for the efficient and stable overexpression of the human IL6 gene. As a multifaceted cytokine involved in both inflammation and lipid metabolism, its stable genomic integration is essential for researching chronic low-grade inflammation in adipose tissue. The viral system features a modular design, offering high flexibility for customization. Comprehensive quality control is performed to ensure product efficacy and the highest standards of safety for cell-based research.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: IL6

Full Name: Interleukin 6

Gene Symbol: CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2

Gene ID: 3569

RefSeq ID-1: NP_000591.1

RefSeq ID-2: NM_000600.5

Summary: IL6 encodes a cytokine involved in immune responses, inflammation, and B-cell maturation. It functions as an endogenous pyrogen and is secreted at sites of acute or chronic inflammation, triggering transcriptional responses via the interleukin-6 receptor complex. Dysregulated IL6 signaling is implicated in various inflammatory and metabolic diseases, including diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated IL-6 levels are also observed during viral infections such as COVID-19.

AdipoUpX™ Human IL6 MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

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