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AdipoUpX™ Human EIF2AK3 AAV Particle (Overexpression)
Cat. No.:
V1225XX374
Species:
Human
Target Gene:
EIF2AK3
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX374-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX374-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX374-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX374-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX374-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX374-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX374-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX374-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX374-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX374-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human EIF2AK3 AAV Particle (Overexpression) is engineered for stable functional validation, achieving efficient expression of the human EIF2AK3 (PERK) gene. This kinase is essential for investigating the endoplasmic reticulum stress response and its contribution to diabetic phenotypes. Clients can select from various AAV serotypes and cell-specific promoters for precise targeting. Comprehensive QC is performed on all viral particle products to ensure experimental reproducibility and safety.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
EIF2AK3
Full Name:
Eukaryotic translation initiation factor 2 alpha kinase 3
Gene Symbol:
PEK; WRS; PERK
Gene ID:
9451
RefSeq ID-1:
NP_004827.4
RefSeq ID-2:
NM_004836.6
Summary:
EIF2AK3 encodes an endoplasmic reticulum stress sensor that attenuates protein synthesis through phosphorylation of eIF2α. This adaptive response links ER stress to metabolic regulation, and chronic EIF2AK3 activation has been associated with obesity-related insulin resistance and mitochondrial dysfunction.
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