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AdipoUpX™ Human IGF1 AAV Particle (Overexpression)
Cat. No.:
V1225XX231
Species:
Human
Target Gene:
IGF1
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX231-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX231-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX231-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX231-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX231-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX231-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX231-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX231-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX231-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX231-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human IGF1 AAV Particle (Overexpression) is a ready-to-use gene delivery tool that has undergone rigorous quality control. It is specifically designed for the stable overexpression of the human IGF1 gene, allowing for in-depth research into growth factor signaling and its cross-talk with insulin pathways. Our AAV platform offers high customization for precise targeted delivery, with comprehensive QC including titer, sterility, and mycoplasma testing performed on every batch to ensure research reliability.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
IGF1
Full Name:
Insulin like growth factor 1
Gene Symbol:
IGF; MGF; IGFI; IGF-I
Gene ID:
3479
RefSeq ID-1:
NP_000609.1
RefSeq ID-2:
NM_000618.5
Summary:
IGF1 encodes a polypeptide hormone structurally similar to insulin, serving as a primary mediator of growth and development throughout the body. The active protein is derived from a precursor and secreted to bind to its specific receptor, activating a crucial signaling cascade. This pathway controls cell proliferation, differentiation, and survival, directly impacting tissue growth and glucose metabolism. While defects primarily result in Insulin-Like Growth Factor I deficiency syndromes, IGF1 signaling is intimately linked to the regulation of body composition and energy balance, influencing fat and muscle mass. The gene uses alternative splicing to produce various isoforms that maintain similar biological activity.
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