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Vitamin B12 test kit

LipoKnoxa™ Human ACOX1 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX334
Species: Human
Target Gene: ACOX1
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human ACOX1 shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX334-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle TTGCAGTGGTCTTCCAAATAT CDS Inquiry
V0126XX334-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle ACTACTGAGTAGTTGATTATT 3' UTR Inquiry
V0126XX334-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GCAGCCAGATTAGTAGAAATT CDS Inquiry
V0126XX334-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle TTGCAGTGGTCTTCCAAATAT CDS Inquiry
V0126XX334-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle ACTACTGAGTAGTTGATTATT 3' UTR Inquiry
V0126XX334-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GCAGCCAGATTAGTAGAAATT CDS Inquiry
V0126XX334-7 AAV3 Lung; Liver; Smooth muscle TTGCAGTGGTCTTCCAAATAT CDS Inquiry
V0126XX334-8 AAV3 Lung; Liver; Smooth muscle ACTACTGAGTAGTTGATTATT 3' UTR Inquiry
V0126XX334-9 AAV3 Lung; Liver; Smooth muscle GCAGCCAGATTAGTAGAAATT CDS Inquiry
V0126XX334-10 AAV4 CNS; Retina; Heart; Lung; Kidney TTGCAGTGGTCTTCCAAATAT CDS Inquiry
V0126XX334-11 AAV4 CNS; Retina; Heart; Lung; Kidney ACTACTGAGTAGTTGATTATT 3' UTR Inquiry
V0126XX334-12 AAV4 CNS; Retina; Heart; Lung; Kidney GCAGCCAGATTAGTAGAAATT CDS Inquiry
V0126XX334-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle TTGCAGTGGTCTTCCAAATAT CDS Inquiry
V0126XX334-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle ACTACTGAGTAGTTGATTATT 3' UTR Inquiry
V0126XX334-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GCAGCCAGATTAGTAGAAATT CDS Inquiry
V0126XX334-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle TTGCAGTGGTCTTCCAAATAT CDS Inquiry
V0126XX334-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle ACTACTGAGTAGTTGATTATT 3' UTR Inquiry
V0126XX334-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GCAGCCAGATTAGTAGAAATT CDS Inquiry
V0126XX334-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle TTGCAGTGGTCTTCCAAATAT CDS Inquiry
V0126XX334-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle ACTACTGAGTAGTTGATTATT 3' UTR Inquiry
V0126XX334-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GCAGCCAGATTAGTAGAAATT CDS Inquiry
V0126XX334-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle TTGCAGTGGTCTTCCAAATAT CDS Inquiry
V0126XX334-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle ACTACTGAGTAGTTGATTATT 3' UTR Inquiry
V0126XX334-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GCAGCCAGATTAGTAGAAATT CDS Inquiry
V0126XX334-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle TTGCAGTGGTCTTCCAAATAT CDS Inquiry
V0126XX334-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle ACTACTGAGTAGTTGATTATT 3' UTR Inquiry
V0126XX334-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GCAGCCAGATTAGTAGAAATT CDS Inquiry
V0126XX334-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human ACOX1 shRNA AAV Particle (Silencing) targets ACOX1, the rate-limiting enzyme in peroxisomal fatty acid beta-oxidation. Silencing ACOX1 via high-efficiency U6 or miR30 shRNA delivery allows for the investigation of lipid accumulation and hepatic steatosis. Our system offers multiple AAV serotypes to ensure optimal tissue-specific tropism. To ensure experimental success, every preparation undergoes total QC verification—covering sequence integrity, functional activity, and mycoplasma detection.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: ACOX1
Full Name: Acyl-CoA oxidase 1
Gene Symbol: AOX; ACOX; SCOX; MITCH; PALMCOX
Gene ID: 51
RefSeq ID-1: NP_001171968.1
RefSeq ID-2: NM_001185039.2
Summary: ACOX1 encodes the first and rate-limiting enzyme of peroxisomal fatty acid β-oxidation. The enzyme catalyzes the initial desaturation of acyl-CoAs, facilitating the breakdown of very long-chain fatty acids. Proper ACOX1 function is essential for lipid homeostasis, and its disruption leads to abnormal lipid accumulation.

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