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AdipoUpX™ Human FOXO1 AAV Particle (Overexpression)
Cat. No.:
V1225XX351
Species:
Human
Target Gene:
FOXO1
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX351-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX351-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX351-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX351-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX351-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX351-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX351-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX351-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX351-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX351-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human FOXO1 AAV Particle (Overexpression) is a ready-to-use gene delivery tool specifically designed for the stable overexpression of the human FOXO1 gene. It serves as a reliable asset for investigating insulin signaling, gluconeogenesis, and adipogenesis. Our AAV platform offers high customization, and all products are validated through comprehensive QC (titer, sterility, and mycoplasma testing) to ensure safety and the reproducibility of results in insulin resistance research.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
FOXO1
Full Name:
Forkhead box O1
Gene Symbol:
FKH1; FKHR; FOXO1A
Gene ID:
2308
RefSeq ID-1:
NP_002006.2
RefSeq ID-2:
NM_002015.3
Summary:
FOXO1 is a member of the forkhead transcription factor family and acts as a major downstream effector of insulin signaling. It coordinates the expression of genes involved in myogenic growth, glucose production in the liver, and fat cell differentiation. Its ability to switch between the nucleus and cytoplasm in response to insulin makes it a master switch for metabolic adaptation.
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