AdipoUpX™ Human ALMS1 MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human ALMS1 MMLV Particle (Overexpression) is a stable integration tool for the specific and efficient overexpression of the human ALMS1 gene. Mutations in this gene lead to Alström syndrome, characterized by morbid obesity and insulin resistance; thus, its stable overexpression is vital for researching ciliary function and adiposity. The MMLV vector integrates into the genome to provide long-lasting expression in dividing cells. Product quality is ensured by rigorous purification and comprehensive quality control validation to ensure the repeatability and safety of experimental results.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: ALMS1

Full Name: ALMS1 centrosome and basal body associated protein

Gene Symbol: ALSS

Gene ID: 7840

RefSeq ID-1: NP_001365383.1

RefSeq ID-2: NM_001378454.1

Summary: ALMS1 encodes a large protein characterized by an extensive tandem-repeat domain and several low-complexity regions. Its primary role is in microtubule organization, particularly in the formation and maintenance of primary cilia and centrosomes. Mutations in this gene are the sole cause of Alstrom Syndrome, a severe and progressive rare disorder. Alstrom Syndrome is characterized by multi-organ dysfunction, including early-onset visual and hearing loss, dilated cardiomyopathy, and severe insulin resistance and obesity, underscoring the vital role of ciliary function in systemic metabolism.

AdipoUpX™ Human ALMS1 MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

Related Products