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ZSTK474
Cat. No.:
OB0225LY-0462
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR and HPLC.
Size:
Product Overview
Description:
ZSTK474 is a novel oral small molecule inhibitor targeting the PI3K signaling pathway with antitumor activity that inhibits the proliferation and survival of tumor cells.
Synonym:
475110-96-4; ZSTK-474; 4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine; 2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine; 2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-bis(morpholino)-1,3,5-triazine; 4,4''-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine
CAS No.:
475110-96-4
Compound CID:
11647372
Formula:
C19H21F2N7O2
Formula Weight:
417.41
Specification
Relative Density:
1.57 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
ZSTK474 can be used to study the role of the PI3K/AKT signaling pathway in cancer or to evaluate its anti-tumor potential during the development of new drugs.
Library Information
Targets:
PI3K
Receptors:
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
Pathways:
PI3K/Akt/mTOR signaling; Autophagy
Plate Number:
AOCL-6
Plate Location:
h9
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10 mM DMSO
DMSO Max Solubility:
8.75 mg/mL; 20.96 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
ALogP:
3.366
HBA_Count:
6
HBD_Count:
0
Rotatable Bond:
4
