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OSI-027
Cat. No.:
OB0225LY-0300
Appearance:
Solid
Purity:
≥97%
Identity:
Confirmed by NMR and LC-MS.
Size:
Product Overview
Description:
OSI-027 is a small molecule compound that mainly acts as a dual PI3K/mTOR inhibitor involved in the regulation of cell growth and metabolism.
Synonym:
ASP4786; OSI027; 936890-98-1; 4-[(5Z)-4-Amino-5-(7-methoxyindol-2-ylidene)-1H-imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexane-1-carboxylic acid; Cyclohexanecarboxylic acid, 4-(4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo(5,1-f)(1,2,4)triazin-7-yl)-, trans-; (1R,4R)-4-(4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid
CAS No.:
936890-98-1
Compound CID:
135398516
Formula:
C21H22N6O3
Formula Weight:
406.44
Specification
Relative Density:
1.59 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
OSI-027 can be used to potently inhibit mTORC1 and mTORC2.
Library Information
Targets:
PIKKs; PI3K/Akt/mTOR pathway
Receptors:
DNA-PK; mTORC1; mTORC2; PI3Kγ
Pathways:
PI3K/Akt/mTOR signaling; Autophagy; DNA damage/DNA repair
Plate Number:
AOCL-4
Plate Location:
g11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10 mM DMSO
DMSO Max Solubility:
15 mg/mL; 36.9 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
ALogP:
3.376
HBA_Count:
5
HBD_Count:
2
Rotatable Bond:
4
