Products
- Anti-Obesity Compound Library
- GPCR/G Protein-Targeted Compounds
- Immunology/Inflammation-Targeted Compounds
- JAK/STAT-Targeted Compounds
- MAPK-Targeted Compounds
- Membrane Transporter/Ion Channel-Targeted Compounds
- Metabolism-Targeted Compounds
- NF-κB-Targeted Compounds
- Microbiology/Virology-Targeted Compounds
- Neuronal Signaling-Targeted Compounds
- PI3K/Akt/mTOR-Targeted Compounds
- Oxidation-reduction-Targeted Compounds
- Proteases/Proteasome-Targeted Compounds
- Stem Cells/Wnt-Targeted Compounds
- Tyrosine Kinase/Adaptors-Targeted Compounds
- Ubiquitin-Targeted Compounds
Online Inquiry
XMD16-5
Cat. No.:
0225LY-0880
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
Add to basket
Product Overview
Description:
XMD16-5 is an inhibitor of TNK2, a protein whose genomic amplification and disrupted signaling are linked to metastasis and late-stage progression in breast, prostate, lung, and gastrointestinal cancers.
Synonym:
1345098-78-3; 2-[4-(4-hydroxypiperidin-1-yl)anilino]-11-methyl-5H-pyrimido[4,5-b][1,4]benzodiazepin-6-one; Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 18; 2-((4-(4-hydroxypiperidin-1-yl)phenyl)amino)-11-methyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one; 2-((4-(4-hydroxypiperidin-1-yl)phenyl)amino)-11-methyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one; 3-[4-(4-Hydroxy-piperidin-1-yl)-phenylamino]-5-methyl-5,11-dihydro-2,4,5,11-tetraaza-dibenzo[a,d]cyclohepten-10-one; 5-{[4-(4-hydroxypiperidin-1-yl)phenyl]amino}-2-methyl-2,4,6,9-tetraazatricyclo[9.4.0.0(3),?]pentadeca-1(15),3,5,7,11,13-hexaen-10-one
CAS No.:
1345098-78-3
Compound CID:
57340666
Formula:
C23H24N6O2
Formula Weight:
416.48
Specification
Targets&IC50:
R806Q: 77 nM; D163E: 16nM
Relative Density:
1.347 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
XMD16-5 can be used in kinase signaling research to study the dual inhibition of BRK and ERK5.
Library Information
Target:
Tyrosinase; PPAR
Receptor:
TNK2; Tyrosinase
Pathways:
Proteases/Proteasome; DNA damage/DNA repair; Metabolism
Plate Number:
AOCL-12
Plate Location:
c9
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
45 mg/mL; 108.05 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
5 mg/mL; 12.01 mM





