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SC-514
Cat. No.:
0225LY-0659
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
SC-514 is a selective, orally active inhibitor of IKK-2 (IC50: 11.2 uM) that works through ATP competition to block gene expression dependent on NF-kappaB.
Synonym:
354812-17-2; 4-Amino-[2,3'-bithiophene]-5-carboxamide; 3-Amino-5-thiophen-3-ylthiophene-2-carboxamide; 3-Amino-5-(3-thienyl)thiophene-2-carboxamide; 3-amino-5-(thiophen-3-yl)thiophene-2-carboxamide; 3-amino-5-(3-thiophenyl)-2-thiophenecarboxamide; (2,3'-Bithiophene)-5-carboxamide, 4-amino-; [2,3'-Bithiophene]-5-carboxamide, 4-amino-
CAS No.:
354812-17-2
Compound CID:
2807869
Formula:
C9H8N2OS2
Formula Weight:
224.3
Specification
Targets&IC50:
IKK2: 11.2±4.7 μM
Relative Density:
1.450 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
SC-514 can be used in inflammatory signaling research to study the selective inhibition of the IKK beta complex.
Library Information
Target:
Aurora kinase; p38 MAPK; Serine protease; IκB/IKK; CDK
Receptor:
Aurora B; CDK2/CyclinA; IKK2; p38α; PRAK
Pathways:
Proteases/Proteasome; Chromatin/Epigenetic; Cell cycle/Checkpoint; NF-κB; MAPK
Plate Number:
AOCL-9
Plate Location:
e5
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
40 mg/mL; 178.33 mM
Ethanol Max Solubility:
2.2 mg/mL; 9.81 mM
ALogP:
1.51
HBA_Count:
1
HBD_Count:
2
Rotatable Bond:
2
