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WAY-600
Cat. No.:
0225LY-0605
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
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Product Overview
Description:
WAY-600 is a selective, ATP-competitive mTOR inhibitor (IC50: 9 nM) that prevents the phosphorylation of mTORC2/P-AKT(S473) and mTORC1/P-S6K(T389) without impacting P-AKT(T308); it is highly selective for mTOR over the alpha and gamma PI3K isoforms.
Synonym:
WAY600; 1062159-35-6; 4-[6-(1H-indol-5-yl)-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-4-yl]morpholine; 4-(6-(1H-Indol-5-yl)-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine; 5-[4-(morpholin-4-yl)-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-6-yl]-1H-indole; 6-(1H-Indol-5-yl)-4-(morpholin-4-yl)-1-{1-[(pyridin-3-yl)methyl]piperidin-4-yl}-1H-pyrazolo[3,4-d]pyrimidine
CAS No.:
1062159-35-6
Compound CID:
25229526
Formula:
C28H30N8O
Formula Weight:
494.59
Specification
Targets&IC50:
mTOR: 9 nM
Relative Density:
1.43 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
WAY-600 can be used in biochemical assays to investigate the potent and ATP-competitive inhibition of the mTOR complex.
Library Information
Target:
Src; PI3K; VEGFR; mTOR
Receptor:
mTOR; PI3Kα; PI3Kγ; Src; VEGFR2
Pathways:
Tyrosine kinase/adaptors; PI3K/Akt/mTOR signaling; Angiogenesis
Plate Number:
AOCL-8
Plate Location:
g10
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
45 mg/mL; 90.98 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
2 mg/mL; 4.04 mM
ALogP:
2.946
HBA_Count:
5
HBD_Count:
1
Rotatable Bond:
5
