Rat transmembrane protein 18 (TMEM18) ELISA kit-Quantitative competitive

Cat. No.: 0126WXX-1909

Assay Type: Quantitative competitive ELISA

Target Species: Rat

Assay Target: TMEM18

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Rat transmembrane protein 18 (TMEM18) ELISA kit-Quantitative competitive

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Product Overview

Description: Rat transmembrane protein 18 (TMEM18) ELISA kit-Quantitative competitive is an ELISA-based in vitro research tool designed specifically for the quantitative detection of TMEM18 in rat samples with a range of 0.5-10 ng/mL and a minimum detectable dose (sensitivity) of 0.1 ng/mL. The kit is highly sensitive and easy to use.

Assay Principle: The ELISA analytical biochemical technique is based on TMEM18 antibody-TMEM18 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TMEM18 antigen targets in samples.

Background: TMEM18 is a transmembrane protein localized to the nuclear envelope, primarily functioning as a sequence-specific transcriptional repressor. Despite its complex molecular functions, TMEM18 holds particular significance in obesity research. Its genetic locus ranks among the strongest genome-wide association study (GWAS)-identified loci associated with human body mass index (BMI), surpassed only by the FTO gene in association strength. TMEM18 is highly expressed in the hypothalamus, particularly in neurons involved in appetite regulation. Studies indicate that TMEM18 expression levels are directly correlated with food intake, energy expenditure, and body weight regulation. Functional loss or variation in TMEM18 may disrupt the central nervous system's regulation of energy signals, thereby promoting obesity.

Synonyms: lncND

Applications: Rat transmembrane protein 18 (TMEM18) ELISA kit-Quantitative competitive is used to quantify TMEM18 in serum, plasma, cell culture supernatants, body fluid, tissue homogenate of rat, providing data to support research in a wide range of areas, including transcriptional regulation, neuroscience, appetite regulation, obesity, and others.

Research Area: Transcriptional regulation; Neuroscience; Appetite regulation; Obesity

Specification

Sample Type: Serum; Plasma; Cell culture supernatants; Body fluid; Tissue homogenate

Detection Range: 0.5-10 ng/mL

Sensitivity: 0.1 ng/mL

Cross-reactivity: No significant cross-reactivity or interference was observed.

Storage: Store at 2-8°C.

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