Rat glucocorticoid receptor-beta (GR-β) ELISA kit

Cat. No.: 0126WXX-293

Assay Type: Quantitative ELISA

Target Species: Rat

Assay Target: GR-β

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Rat glucocorticoid receptor-beta (GR-β) ELISA kit

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Product Overview

Description: Rat glucocorticoid receptor-beta (GR-β) ELISA kit is an ELISA-based in vitro research tool designed specifically for the quantitative detection of GR-β in rat samples. The kit is highly sensitive and easy to use.

Assay Principle: The ELISA analytical biochemical technique is based on GR-β antibody-GR-β antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GR-β antigen targets in samples.

Background: GR-β is a splice isoform of the glucocorticoid receptor (GR). Unlike the physiologically active GR-α we are familiar with, GR-β cannot bind glucocorticoids and thus cannot mediate the classical glucocorticoid signaling pathway. Its primary function is believed to be the negative regulation of GR-α activity. It can form heterodimers with GR-α, preventing GR-α from entering the cell nucleus and binding to DNA, thereby inhibiting GR-α-mediated gene transcription. Consequently, GR-β is regarded as an endogenous inhibitor or antagonist of glucocorticoid action. Changes in GR-β levels may be associated with diseases such as obesity.

Synonyms: GRb; GR-beta

Applications: Rat glucocorticoid receptor-beta (GR-β) ELISA kit is used to quantify GR-β in biological samples of rat, providing data to support research in a wide range of areas, including signal transduction, endocrinology, hormone metabolism, obesity, and others.

Research Area: Signal transduction; Endocrinology; Hormone metabolism; Obesity

Specification

Sample Type: Biological samples

Cross-reactivity: No significant cross-reactivity or interference was observed.

Storage: Store at 2-8°C.

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