Porcine tartrate resistant acid phosphatase 5b (TRACP 5b) ELISA kit (15.6-1000 pg/mL)

Cat. No.: 0126WXX-1993

Assay Type: Quantitative sandwich ELISA

Target Species: Porcine

Assay Target: TRACP 5b

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Porcine tartrate resistant acid phosphatase 5b (TRACP 5b) ELISA kit (15.6-1000 pg/mL)

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Product Overview

Description: Porcine tartrate resistant acid phosphatase 5b (TRACP 5b) ELISA kit (15.6-1000 pg/mL) is an ELISA-based in vitro research tool designed specifically for the quantitative detection of TRACP 5b in porcine samples with a range of 15.6-1000 pg/mL and a minimum detectable dose (sensitivity) of 5 pg/mL. The kit is highly sensitive and easy to use.

Assay Principle: The ELISA analytical biochemical technique is based on TRACP 5b antibody-TRACP 5b antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TRACP 5b antigen targets in samples.

Background: TRACP 5B, a metallophosphoesterase located at 19p13.2, encodes a tartrate-resistant acid phosphatase (EC 3.1.3.2) essential for bone resorption and the negative regulation of inflammatory cytokines, including TNF and interleukin-1 beta. By dephosphorylating osteopontin and bone sialoprotein, it maintains skeletal integrity and immune homeostasis; consequently, inactivating mutations lead to SPENCDI, while its elevated expression serves as a biomarker for various leukemias and Gaucher disease. In the context of metabolic health, TRACP 5B is increasingly recognized for its role in obesity-driven chronic inflammation, as its regulation of osteopontin signaling and macrophage activity directly influences the adipose tissue remodeling and systemic insulin resistance associated with excessive weight gain.

Synonyms: ACP5; TRAP5b; SPENCDI; TRACP-5b

Applications: Porcine tartrate resistant acid phosphatase 5b (TRACP 5b) ELISA kit (15.6-1000 pg/mL) is used to quantify TRACP 5b in serum, plasma, cell culture supernatant, and organizations of porcine tissues, providing data to support research in a wide range of areas, including signal transduction, metabolism, obesity, and others.

Research Area: Signal transduction; Metabolism; Obesity