LipoKnoxa™ Human TCF7L2 shRNA Lentiviral Particle (Silencing)

Sub Cat. No.	TargetSeq	Region	Inquiry
V0126XX505-1	CTCCGCACCCTCCAGATATAT	CDS	Inquiry
V0126XX505-2	CCGAAAGTTTCCGAGACAAAT	CDS	Inquiry
V0126XX505-3	CAAGATGGAGGGCTCTTTAAG	CDS	Inquiry
V0126XX505-4	Other		Inquiry

Product Overview

Description: LipoKnoxa™ Human TCF7L2 shRNA Lentiviral Particle (Silencing) targets the strongest genetic risk factor for type 2 diabetes, regulating pro-insulin processing. Our RNAi platform develops this product using both U6-driven shRNA for maximal silencing and miR30-based systems for physiologically optimized expression. Every preparation undergoes total QC verification—covering functional titer, sequence identity, and sterility—ensuring scientifically sound results.

Production Cell Line: HEK293T

Promoter: U6; CMV; EF1α; CAG; UBC

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Comprehensive sequencing and PCR analyses were performed to verify the accurate genomic sequence of all viral preparations.

Sterility Test: Confirmed sterile via rigorous microbial analysis; free of bacterial and fungal contamination.

Mycoplasma Test: Rigorous quality control testing has confirmed the absence of mycoplasma contamination in this viral preparation.

Other QC: Customized supplementary testing and in vitro/in vivo assessments are available to verify post-silencing gene expression and biological functionality, ensuring the viral preparations meet the specific potency requirements of your gene interference project.

Storage: Store at -80°C for long-term preservation. Immediate transfer upon delivery is required to prevent loss of viral activity.

Stability: Shelf life: 6–12 months at -80°C (extended stability up to 2 years). Post-thaw: Stable at 4°C for 2–3 weeks without significant degradation of functional titers.

Shipping Condition: Products are delivered on dry ice to maintain the cold chain. Upon arrival, please ensure the presence of dry ice and transfer the vials immediately to -80°C storage.

Handling Notes: Avoid repeated freeze-thaw cycles. Aliquot into low-protein-binding tubes immediately after receipt to maintain optimal activity. For safety and contamination control, all viral handling must be performed inside a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: We ensure product integrity through rigorous QC, but we do not guarantee results in specific research contexts. Proper storage, handling, and total compliance with biosafety laws and safety protocols remain the sole responsibility of the user.

Target Profile

Gene Name: TCF7L2

Full Name: Transcription factor 7 like 2

Gene Symbol: TCF4; TCF-4

Gene ID: 6934

RefSeq ID-1: NP_001139746.1

RefSeq ID-2: NM_001146274.2

Summary: TCF7L2 encodes a transcription factor containing a high mobility group (HMG) box and functions as a critical regulator of the Wnt signaling pathway. It has a significant role in glucose homeostasis, and variants of this gene are associated with increased susceptibility to type 2 diabetes. Multiple transcript variants encoding distinct isoforms have been identified.

LipoKnoxa™ Human TCF7L2 shRNA Lentiviral Particle (Silencing)

Product Overview

Specification

Target Profile

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