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Vitamin B12 test kit

LipoKnoxa™ Human FABP4 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX323
Species: Human
Target Gene: FABP4
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human FABP4 shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX323-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GATTTAGCAAGCAACTAATTT 3' UTR Inquiry
V0126XX323-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CGTCACTTCCACGAGAGTTTA CDS Inquiry
V0126XX323-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GCATTGAACTCTACAACATTC 3' UTR Inquiry
V0126XX323-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GATTTAGCAAGCAACTAATTT 3' UTR Inquiry
V0126XX323-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CGTCACTTCCACGAGAGTTTA CDS Inquiry
V0126XX323-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GCATTGAACTCTACAACATTC 3' UTR Inquiry
V0126XX323-7 AAV3 Lung; Liver; Smooth muscle GATTTAGCAAGCAACTAATTT 3' UTR Inquiry
V0126XX323-8 AAV3 Lung; Liver; Smooth muscle CGTCACTTCCACGAGAGTTTA CDS Inquiry
V0126XX323-9 AAV3 Lung; Liver; Smooth muscle GCATTGAACTCTACAACATTC 3' UTR Inquiry
V0126XX323-10 AAV4 CNS; Retina; Heart; Lung; Kidney GATTTAGCAAGCAACTAATTT 3' UTR Inquiry
V0126XX323-11 AAV4 CNS; Retina; Heart; Lung; Kidney CGTCACTTCCACGAGAGTTTA CDS Inquiry
V0126XX323-12 AAV4 CNS; Retina; Heart; Lung; Kidney GCATTGAACTCTACAACATTC 3' UTR Inquiry
V0126XX323-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GATTTAGCAAGCAACTAATTT 3' UTR Inquiry
V0126XX323-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CGTCACTTCCACGAGAGTTTA CDS Inquiry
V0126XX323-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GCATTGAACTCTACAACATTC 3' UTR Inquiry
V0126XX323-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GATTTAGCAAGCAACTAATTT 3' UTR Inquiry
V0126XX323-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CGTCACTTCCACGAGAGTTTA CDS Inquiry
V0126XX323-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GCATTGAACTCTACAACATTC 3' UTR Inquiry
V0126XX323-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GATTTAGCAAGCAACTAATTT 3' UTR Inquiry
V0126XX323-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CGTCACTTCCACGAGAGTTTA CDS Inquiry
V0126XX323-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GCATTGAACTCTACAACATTC 3' UTR Inquiry
V0126XX323-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GATTTAGCAAGCAACTAATTT 3' UTR Inquiry
V0126XX323-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CGTCACTTCCACGAGAGTTTA CDS Inquiry
V0126XX323-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GCATTGAACTCTACAACATTC 3' UTR Inquiry
V0126XX323-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GATTTAGCAAGCAACTAATTT 3' UTR Inquiry
V0126XX323-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CGTCACTTCCACGAGAGTTTA CDS Inquiry
V0126XX323-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GCATTGAACTCTACAACATTC 3' UTR Inquiry
V0126XX323-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human FABP4 shRNA AAV Particle (Silencing) focuses on the targeted inhibition of FABP4, which is central to systemic glucose and lipid homeostasis. This tool provides two distinct expression strategies: high-potency U6 systems and physiologically optimized miR30-based architectures to reduce cellular stress during adipocyte studies. To ensure optimal delivery to adipose depots, multiple AAV serotypes are available for selection. Every batch is validated through total quality control, including high-precision titering and sterility testing, ensuring data reproducibility.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: FABP4
Full Name: Fatty acid binding protein 4
Gene Symbol: aP2; ALBP; AFABP; A-FABP; HEL-S-104
Gene ID: 2167
RefSeq ID-1: NP_001433.1
RefSeq ID-2: NM_001442.3
Summary: FABP4 encodes an adipocyte-enriched fatty acid–binding protein that facilitates intracellular trafficking and metabolism of long-chain fatty acids. By coordinating lipid uptake and storage within adipose tissue, FABP4 contributes to adipocyte function and systemic energy balance. Dysregulation of FABP4 has been linked to obesity and metabolic disease.

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