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LipoKnoxa™ Human DYRK1B shRNA Ad5 Particle (Silencing)
Cat. No.:
V0126XX30
Species:
Human
Target Gene:
DYRK1B
Vector System:
Adenovirus
Modulation Type:
Silencing (shRNA)
SPECIFIC INQUIRY
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| Sub Cat. No. | TargetSeq | Region | Inquiry |
|---|---|---|---|
| V0126XX30-1 | ACGGAGATGAAGTACTATATA | CDS | Inquiry |
| V0126XX30-2 | ACCGCTACAGCAACCGATATT | CDS | Inquiry |
| V0126XX30-3 | CACGGAGATGAAGTACTATAT | CDS | Inquiry |
| V0126XX30-4 | Other | Inquiry |
Product Overview
Description:
LipoKnoxa™ Human DYRK1B shRNA Ad5 Particle (Silencing) targets the DYRK1B kinase, which is involved in the balance between muscle and fat differentiation. Knocking down this gene is key to researching metabolic syndrome and abdominal obesity. Each viral preparation is subjected to total QC verification—covering sequence identity and functional activity—to ensure that your experimental results are both safe and scientifically sound.
Production Cell Line:
HEK293
Viral Backbone:
Adenovirus type 5 (dE1/E3)
Promoter:
U6; CMV; EF1α; CAG; UBC
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
All viral preparations are validated via Sequencing and PCR to ensure 100% sequence identity and the structural integrity of the vector genomes.
Sterility Test:
This product has been certified sterile following comprehensive microbial growth analysis, confirming the absence of bacterial and fungal contamination.
Mycoplasma Test:
This product was certified negative for mycoplasma contamination following stringent QC analysis, ensuring the absence of all mycoplasmal agents.
Other QC:
Beyond standard protocols, we offer customized knockdown efficiency validation through in vitro and in vivo assessments. This includes precise analysis of mRNA/protein reduction and subsequent biological responses to ensure the functional potency of the shRNA-mediated gene silencing.
Storage:
Upon receipt, viral preparations should be immediately transferred to -80°C for long-term storage to ensure maximum stability and maintain product integrity.
Stability:
This product maintains excellent biological activity for 6–12 months (and up to 2 years in specific cases) when stored continuously at -80°C. Once thawed, the working solution remains stable for 2–3 weeks at 4°C without significant loss of viral potency.
Shipping Condition:
All viral preparations are shipped on dry ice to ensure maximum biological activity and stability during transit.
Handling Notes:
Viral particles are susceptible to temperature fluctuations and freeze-thaw cycles. To preserve functional titers, it is essential to aliquot the vector into low-protein-binding tubes immediately upon first thaw. To ensure experimental success and biological safety, all procedures must be conducted within a certified biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
While our products are committed to excellence through rigorous internal QC inspections, we cannot guarantee specific performance or experimental outcomes due to the inherent complexity of biological systems. Users assume full responsibility for product storage, handling, and strict compliance with all applicable safety protocols, biosafety requirements, and legal regulations during all operational processes.
Target Profile
Gene Name:
DYRK1B
Full Name:
Dual specificity tyrosine phosphorylation regulated kinase 1B
Gene Symbol:
MIRK; AOMS3
Gene ID:
9149
RefSeq ID-1:
NP_004705.1
RefSeq ID-2:
NM_004714.3
Summary:
DYRK1B encodes a nuclear-localized dual-specificity protein kinase involved in cell cycle regulation. The activity and expression of DYRK1B are altered in certain tumor types, indicating a role in cell proliferation control. Importantly, mutations in DYRK1B have been identified as the cause of abdominal obesity–metabolic syndrome 3, linking this kinase directly to metabolic dysfunction. The gene generates multiple transcript variants through alternative splicing, further contributing to its functional diversity.
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