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KU-0060648
Cat. No.:
0225LY-0586
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
Add to basket
Product Overview
Description:
KU-0060648 acts as a dual inhibitor of PI3K (alpha, beta, delta) and DNA-PK with IC50 values of 0.1 nM, 0.5 nM, 4 nM, and 8.6 nM, respectively, though it is less effective against PI3K gamma.
Synonym:
KU0060648; 881375-00-4; 2-(4-ethylpiperazin-1-yl)-N-[4-(2-morpholin-4-yl-4-oxochromen-8-yl)dibenzothiophen-1-yl]acetamide; 1-Piperazineacetamide, 4-ethyl-N-(4-(2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl)-1-dibenzothienyl); 2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide; 4-Ethyl-N-(4-(2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl)-1-dibenzothienyl)-1-piperazineacetamide
CAS No.:
881375-00-4
Compound CID:
11964036
Formula:
C33H34N4O4S
Formula Weight:
582.71
Specification
Targets&IC50:
PI3Kδ: 0.1 nM; PI3Kβ: 0.5 nM; PI3Kα: 4 nM
Relative Density:
1.337 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
KU-0060648 can be used in DNA repair research to study the combined inhibition of DNA-PK and the PI3K pathway.
Library Information
Target:
mTOR; DNA-PK; PI3K
Receptor:
DNA-PK; mTOR; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
Pathways:
PI3K/Akt/mTOR signaling; DNA damage/DNA repair
Plate Number:
AOCL-8
Plate Location:
e11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
