Human hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL) ELISA kit-Quantitative sandwich

Cat. No.: 0126WXX-354

Assay Type: Quantitative sandwich ELISA

Target Species: Human

Assay Target: HMGCL

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Human hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL) ELISA kit-Quantitative sandwich

INQUIRY Datasheet MSDS

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Product Overview

Description: Human hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL) ELISA kit is an ELISA-based in vitro research tool designed specifically for the quantitative detection of HMGCL in human samples. The kit is highly sensitive and easy to use.

Assay Principle: The ELISA analytical biochemical technique is based on HMGCL antibody-HMGCL antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HMGCL antigen targets in samples.

Background: HMGCL is a key enzyme that functions within mitochondria. It serves as a central enzyme in the ketogenesis pathway, responsible for cleaving hydroxymethylglutaroyl-CoA into acetoacetate and acetyl-CoA. Ketogenesis is the process by which the body converts fat into ketone bodies as an energy source during starvation or low-carbohydrate diets. Therefore, HMGCL is critically important in this process. While HMGCL itself does not directly cause obesity, its activity as a key enzyme for the efficient utilization of fatty acids is closely linked to how the body processes and consumes fat. Consequently, research into HMGCL function contributes to a deeper understanding of energy metabolism in obesity and offers new insights for developing therapeutic approaches targeting enhanced lipolysis.

Synonyms: 3-Hydroxymethyl-3-methylglutaryl-CoA lyase; Hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 1; HL; HMG-CoA lyase; Hydroxymethylglutaricaciduria; 3-Hydroxy-3-methylglutarate-CoA lyase; 3-Hydroxymethyl-3-methylglutaryl-Coenzyme A lyase; Mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase

Applications: Human hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL) ELISA kit is used to quantify HMGCL in human samples, providing data to support research in a wide range of areas, including metabolism, obesity, and others.

Research Area: Metabolism; Obesity

Specification

Sample Type: Human samples

Detection Range: 0.625-20 ng/mL

Sensitivity: 0.1 ng/mL

Precision (Intra-assay): CV<15%

Precision (Inter-assay): CV<15%

Cross-reactivity: No significant cross-reactivity or interference was observed.

Storage: Store at 2-8°C.

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