Human glucagon-like peptide 1 receptor (GLP-1R) ELISA kit (0.156-10.0 ng/mL)

Cat. No.: 0126WXX-199

Assay Type: Quantitative ELISA

Target Species: Human

Assay Target: GLP-1R

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Human glucagon-like peptide 1 receptor (GLP-1R) ELISA kit (0.156-10.0 ng/mL)

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Product Overview

Description: Human glucagon-like peptide 1 receptor (GLP-1R) ELISA kit (0.156-10.0 ng/mL) is an ELISA-based in vitro research tool designed specifically for the quantitative detection of GLP-1R in human samples with a range of 0.156-10.0 ng/mL. The kit is highly sensitive and easy to use.

Assay Principle: The microtiter plate provided in this kit is pre-immobilized with an antibody specific to GLP-1R. Standards or samples are added to the wells along with a biotin-conjugated polyclonal antibody and avidin-HRP. Following incubation, a TMB substrate solution is introduced. Color development occurs only in wells containing the GLP-1R sandwich complex. The enzymatic reaction is halted by adding a sulphuric acid solution, and the color change is measured spectrophotometrically at 450 nm ± 2 nm. The concentration of GLP-1R in the samples is determined by comparing the O.D. of the samples to the standard curve.

Background: GLP-1R is a G protein-coupled receptor located on the cell membrane. It serves as the primary receptor for the endogenous hormone GLP-1 and is widely distributed across multiple tissues, including pancreatic β-cells, the hypothalamus, the gastrointestinal tract, and the heart. When GLP-1 binds to and activates the GLP-1R, it initiates a series of intracellular signaling pathways that influence insulin secretion, blood glucose homeostasis, appetite, and gastrointestinal motility. The GLP-1R plays a pivotal role in obesity treatment and is currently one of the most effective and sought-after targets for anti-obesity drugs. Activating this receptor transmits potent satiety signals to the brain, effectively suppressing appetite and reducing cravings for high-calorie foods.

Synonyms: GLP 1 receptor; GLP-1 receptor; GLP1R

Applications: Human glucagon-like peptide 1 receptor (GLP-1R) ELISA kit (0.156-10.0 ng/mL) is used to quantify GLP-1R in serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids of human, providing data to support research in a wide range of areas, including endocrinology, cardiovascular, obesity, and others.

Research Area: Endocrinology; Cardiovascular; Obesity

Specification

Sample Type: Serum; Plasma; Tissue homogenates; Cell culture supernates; Other biological fluids

Detection Range: 0.156-10.0 ng/mL

Cross-reactivity: No significant cross-reactivity or interference was observed.

Storage: Store at 4°C.

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