Human adipose triglyceride lipase (ATGL) ELISA kit (0.625-40 ng/mL)

Cat. No.: 0126WXX-1407

Assay Type: Quantitative ELISA

Target Species: Human

Assay Target: ATGL

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Human adipose triglyceride lipase (ATGL) ELISA kit (0.625-40 ng/mL)

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Product Overview

Description: Human adipose triglyceride lipase (ATGL) ELISA kit (0.625-40 ng/mL) is an ELISA-based in vitro research tool designed specifically for the quantitative detection of ATGL in human samples with a range of 0.625-40 ng/mL and a minimum detectable dose (sensitivity) of <0.1 ng/mL. The kit is highly sensitive and easy to use.

Assay Principle: The ELISA analytical biochemical technique is based on ATGL antibody-ATGL antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ATGL antigen targets in samples.

Background: ATGL, also known as PNPLA2, is the rate-limiting enzyme in the intracellular lipolysis pathway and a key member of the Triglyceride Lipase (TGL) family. ATGL primarily catalyzes the first step in the hydrolysis of triglycerides (TG) stored in cellular lipid droplets into diglycerides and free fatty acids (FFA). In obesity research, ATGL occupies a central position as it directly governs energy storage and mobilization. Dysregulation of ATGL activity leads to ectopic TG accumulation in non-adipose tissues such as the liver and muscle, triggering lipotoxicity and associated pathological responses. Furthermore, ATGL activity influences FFA release, thereby affecting systemic energy balance and adipose tissue inflammation. Consequently, ATGLs represent key targets for understanding lipolysis dysregulation and obesity-related metabolic complications.

Synonyms: PEDF-R; TTS2; Desnutrin; Pigment epithelium-derived factor; Transport-secretion protein 2; Calcium-independent phospholipase A2; PNPLA2; Patatin like phospholipase domain containing protein 2

Applications: Human adipose triglyceride lipase (ATGL) ELISA kit (0.625-40 ng/mL) is used to quantify ATGL in serum, plasma, tissue homogenates, and other biological fluids of humans, providing data to support research in a wide range of areas, including lipid metabolism, energy balance and thermogenesis, and others.

Research Area: Lipid metabolism; Energy balance and thermogenesis

Specification

Sample Type: Serum; Plasma; Tissue homogenates; Other biological fluids

Detection Range: 0.625-40 ng/mL

Sensitivity: <0.1 ng/mL

Cross-reactivity: No significant cross-reactivity or interference was observed.

Storage: Store at 2-8°C.

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