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Evacetrapib
Cat. No.:
0225LY-1237
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, and LC-MS.
Size:
Add to basket
Product Overview
Description:
Evacetrapib serves as a selective and potent CETP inhibitor (IC50: 5.5 nM) that increases HDL levels without negatively impacting blood pressure or aldosterone.
Synonym:
LY2484595; 1186486-62-3; Evacetrapib (LY2484595); LY-2484595; LY 2484595; 4-[[(5S)-5-[[3,5-bis(trifluoromethyl)phenyl]methyl-(2-methyltetrazol-5-yl)amino]-7,9-dimethyl-2,3,4,5-tetrahydro-1-benzazepin-1-yl]methyl]cyclohexane-1-carboxylic acid; (1S,4r)-4-(((S)-5-((3,5-bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methyl)cyclohexanecarboxylic acid; 4-trans-(((S)-5-((3,5-Bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methyl)cyclohexanecarboxylic acid
CAS No.:
1186486-62-3
Compound CID:
49836058
Formula:
C31H36F6N6O2
Formula Weight:
638.65
Specification
Targets&IC50:
CETP: 5.5 nM
Relative Density:
1.4 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Evacetrapib can be used in drug discovery to evaluate the efficacy of potent CETP inhibition in managing dyslipidemia.
Library Information
Target:
CETP
Receptor:
CETP
Pathways:
Metabolism
Plate Number:
AOCL-16
Plate Location:
h4
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
13 mg/mL; 20.36 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
11 mg/mL; 17.22 mM
ALogP:
8.617
HBA_Count:
4
HBD_Count:
0
Rotatable Bond:
9
