AT9283

Cat. No.: OB0225LY-0457

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: AT9283 is a multi-targeted kinase inhibitor that targets multiple cancer cell signaling pathways.

Synonym: J-504568; 896466-04-9; 1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea; 1-Cyclopropyl-3-[5-[6-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]urea; 3-cyclopropyl-1-{3-[(2Z)-5-(morpholin-4-ylmethyl)-1,3-benzodiazol-2-ylidene]-1,2-dihydropyrazol-4-yl}urea

CAS No.: 896466-04-9

Compound CID: 135398495

Formula: C₁₉H₂₃N₇O₂

Formula Weight: 381.43

Specification

Relative Density: 1.45 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: AT9283 can be used to study the mechanisms of tumor cell proliferation and survival.

Library Information

Targets: Serine/Threonine kinases; Tyrosine kinases

Receptors: Abl1 (T315I); Aurora A; Aurora B; Bcr-Abl; FLT3; JAK2; JAK3

Pathways: Apoptosis; Cytoskeletal signaling; Cell cycle/Checkpoint; Angiogenesis; Tyrosine kinase/adaptors; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem cells

Plate Number: AOCL-6

Plate Location: h4

Empty Location: a1-h1; a12-h12

Container: 96-well plate

Formulation: 10 mM DMSO

DMSO Max Solubility: 71 mg/mL; 186.1 mM

Water Max Solubility: <1 mg/mL (insoluble or slightly soluble)

Ethanol Max Solubility: 22 mg/mL; 57.7 mM

ALogP: 1.51

HBA_Count: 4

HBD_Count: 4

Rotatable Bond: 5