AdipoUpX™ Human SH2B1 MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human SH2B1 MMLV Particle (Overexpression) is a high-titer, ready-to-use MMLV retroviral particle professionally engineered for the stable overexpression of the human SH2B1 gene. This adapter protein is essential for enhancing leptin and insulin signaling sensitivity. Stable genomic integration in dividing cells makes it an ideal asset for researching the molecular basis of leptin resistance. Our vector platform supports flexible customization of reporter genes, and all products pass comprehensive quality control (titer, sterility, and mycoplasma testing).

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: SH2B1

Full Name: SH2B adaptor protein 1

Gene Symbol: PSM; SH2B

Gene ID: 25970

RefSeq ID-1: NP_001139267.1

RefSeq ID-2: NM_001145795.2

Summary: SH2B1 encodes an adaptor protein containing an SH2 domain that mediates intracellular kinase activation. It functions in signaling downstream of cytokine and growth factor receptors and may influence cellular transformation and metabolic processes. Alternative splicing generates multiple transcript variants, highlighting the complexity of SH2B1’s roles in regulating energy balance and cellular signaling pathways.

AdipoUpX™ Human SH2B1 MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

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