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AdipoUpX™ Human PHB1 AAV Particle (Overexpression)
Cat. No.:
V1225XX388
Species:
Human
Target Gene:
PHB1
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX388-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX388-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX388-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX388-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX388-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX388-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX388-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX388-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX388-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX388-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human PHB1 AAV Particle (Overexpression) has undergone comprehensive quality control and efficiently expresses the human PHB1 gene. As a vital regulator of mitochondrial fitness and energy production, it is an ideal tool for researching bioenergetics and cellular lifespan in metabolic models. Our platform offers highly customizable services for precise targeting, and safety is ensured by full QC screening (titer, sterility, and mycoplasma detection) for all viral products.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
PHB1
Full Name:
Prohibitin 1
Gene Symbol:
PHB; BAP32; HEL-215; HEL-S-54e
Gene ID:
5245
RefSeq ID-1:
NP_001268425.1
RefSeq ID-2:
NM_001281496.2
Summary:
PHB1 is a highly conserved gene whose product has been implicated in cellular senescence, mitochondrial integrity, and tumor suppression. Antiproliferative effects have been attributed to regulatory elements within the 3′ untranslated region, which may act as a trans-acting RNA. Given its role in mitochondrial function and energy regulation, PHB1 has been linked to metabolic homeostasis and adipocyte biology, processes that are disrupted in obesity. Several pseudogenes and multiple splice variants have been reported.
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