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AdipoUpX™ Human ADIPOQ AAV Particle (Overexpression)
Cat. No.:
V1125XX19
Species:
Human
Target Gene:
ADIPOQ
Vector System:
AAV
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1125XX19-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1125XX19-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1125XX19-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1125XX19-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1125XX19-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1125XX19-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1125XX19-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1125XX19-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1125XX19-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1125XX19-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human ADIPOQ AAV Particle (Overexpression) is a ready-to-use, high-titer viral particle product that achieves stable and efficient expression of the human ADIPOQ gene through an optimized strong promoter. This gene codes for Adiponectin, a crucial adipokine that acts as a systemic protector of metabolic health. This AAV is an ideal tool for studying ADIPOQ's effects on insulin sensitization, fatty acid oxidation, and its anti-inflammatory signaling role. All viral products undergo rigorous internal quality control to ensure reliability for obesity and metabolic research. Our customizable platform also allows flexible selection of serotypes and fluorescent labels for targeted delivery and multifunctional tracking.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
ADIPOQ
Full Name:
Adiponectin, C1Q and collagen domain containing
Gene Symbol:
ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1
Gene ID:
9370
RefSeq ID:
NM_001177800.2, NP_001171271.1
Summary:
The protein encoded by the ADIPOQ gene is a unique adipokine structurally similar to collagen and complement C1q. Its distinctiveness lies in its exclusive expression by adipose tissue and high circulating concentrations in plasma. Adiponectin mediates systemic metabolic signaling by binding receptors on target cells, enhancing insulin sensitivity and promoting glucose and fatty acid metabolism. Reduced plasma adiponectin levels serve as a key indicator for insulin resistance, type 2 diabetes, and cardiovascular disease progression, with genetic mutations directly causing adiponectin deficiency.
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