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AdipoUpX™ Human UCP3 AAV Particle (Overexpression)
Cat. No.:
V1125XX17
Species:
Human
Target Gene:
UCP3
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1125XX17-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1125XX17-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1125XX17-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1125XX17-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1125XX17-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1125XX17-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1125XX17-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1125XX17-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1125XX17-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1125XX17-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human UCP3 AAV Particle (Overexpression) is a ready-to-use, high-titer AAV product that undergoes rigorous QC and ensures efficient and stable expression of the human UCP3 gene through an optimized strong promoter. Specifically designed for rapid validation of UCP3's effects on mitochondrial uncoupling, thermogenesis (heat generation), and protection against lipid-induced oxidative stress in skeletal muscle and brown fat models, it serves as a reliable tool for accelerating metabolic rate research. Our customizable platform allows flexible selection of serotypes and fluorescent labels for targeted delivery and multifunctional tracking.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
UCP3
Full Name:
Uncoupling protein 3
Gene Symbol:
SLC25A9
Gene ID:
7352
RefSeq ID:
NM_003356.4, NP_003347.1
Summary:
The UCP3 gene encodes a protein that functions as an anion transporter spanning the mitochondrial inner membrane. UCP3's key role is establishing a mitochondrial proton leakage channel that uncouples oxidative phosphorylation from ATP synthesis. In essence, it dissipates the proton gradient, releasing energy as heat, making it a significant thermogenic factor in skeletal muscle. This protein also assists in exporting excess fatty acids from the mitochondrial matrix, serving as a key protective mechanism against oxidative stress induced by lipid overload.
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