Inquiry
Products
Online Inquiry

Please note that we are not a pharmacy or clinic, so we are unable to see patients and do not offer diagnostic and treatment services for individuals.

Vitamin B12 test kit

LipoKnoxa™ Human DGAT2 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX379
Species: Human
Target Gene: DGAT2
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human DGAT2 shRNA AAV Particle (Silencing)
INQUIRY Datasheet MSDS
SPECIFIC INQUIRY
Fluorescent Reporters:
Titer:
Size:
Add to basket
Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX379-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle ATGGGTGTCTGTGGGTTATTT 3' UTR Inquiry
V0126XX379-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GTTCTAGGTGGTGGCTAAATC 3' UTR Inquiry
V0126XX379-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CCGGGACACCATAGACTATTT CDS Inquiry
V0126XX379-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle ATGGGTGTCTGTGGGTTATTT 3' UTR Inquiry
V0126XX379-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GTTCTAGGTGGTGGCTAAATC 3' UTR Inquiry
V0126XX379-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CCGGGACACCATAGACTATTT CDS Inquiry
V0126XX379-7 AAV3 Lung; Liver; Smooth muscle ATGGGTGTCTGTGGGTTATTT 3' UTR Inquiry
V0126XX379-8 AAV3 Lung; Liver; Smooth muscle GTTCTAGGTGGTGGCTAAATC 3' UTR Inquiry
V0126XX379-9 AAV3 Lung; Liver; Smooth muscle CCGGGACACCATAGACTATTT CDS Inquiry
V0126XX379-10 AAV4 CNS; Retina; Heart; Lung; Kidney ATGGGTGTCTGTGGGTTATTT 3' UTR Inquiry
V0126XX379-11 AAV4 CNS; Retina; Heart; Lung; Kidney GTTCTAGGTGGTGGCTAAATC 3' UTR Inquiry
V0126XX379-12 AAV4 CNS; Retina; Heart; Lung; Kidney CCGGGACACCATAGACTATTT CDS Inquiry
V0126XX379-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle ATGGGTGTCTGTGGGTTATTT 3' UTR Inquiry
V0126XX379-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GTTCTAGGTGGTGGCTAAATC 3' UTR Inquiry
V0126XX379-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CCGGGACACCATAGACTATTT CDS Inquiry
V0126XX379-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle ATGGGTGTCTGTGGGTTATTT 3' UTR Inquiry
V0126XX379-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GTTCTAGGTGGTGGCTAAATC 3' UTR Inquiry
V0126XX379-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CCGGGACACCATAGACTATTT CDS Inquiry
V0126XX379-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle ATGGGTGTCTGTGGGTTATTT 3' UTR Inquiry
V0126XX379-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GTTCTAGGTGGTGGCTAAATC 3' UTR Inquiry
V0126XX379-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CCGGGACACCATAGACTATTT CDS Inquiry
V0126XX379-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle ATGGGTGTCTGTGGGTTATTT 3' UTR Inquiry
V0126XX379-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GTTCTAGGTGGTGGCTAAATC 3' UTR Inquiry
V0126XX379-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CCGGGACACCATAGACTATTT CDS Inquiry
V0126XX379-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle ATGGGTGTCTGTGGGTTATTT 3' UTR Inquiry
V0126XX379-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GTTCTAGGTGGTGGCTAAATC 3' UTR Inquiry
V0126XX379-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CCGGGACACCATAGACTATTT CDS Inquiry
V0126XX379-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human DGAT2 shRNA AAV Particle (Silencing) targets DGAT2, which plays a major role in hepatic triglyceride synthesis. Our RNAi platform develops this product using both U6-driven shRNA for maximal silencing and miR30-based systems for physiologically optimized expression. Multiple AAV serotypes are available to ensure optimal delivery to the liver. Every product is backed by comprehensive QC documentation, confirming functional titer, sequence identity, and sterility for optimal experimental reliability.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: DGAT2
Full Name: Diacylglycerol O-acyltransferase 2
Gene Symbol: ARAT; HMFN1045; GS1999FULL
Gene ID: 84649
RefSeq ID-1: NP_001240820.1
RefSeq ID-2: NM_001253891.2
Summary: DGAT2 catalyzes the final and essential step in triglyceride synthesis by joining diacylglycerol with fatty acyl-CoAs. Unlike its counterpart DGAT1, this enzyme operates effectively at low magnesium concentrations. As the primary engine for creating storage fat, DGAT2 is a major focus for research into obesity, fatty liver disease, and lipid droplet formation.

Related Products

Inquiry
0
Inquiry Basket

Recognizing the multifaceted nature of obesity, we leverage our expertise in preclinical research to provide tailored solutions that address the unique challenges faced by our partners in the biotechnology and pharmaceutical industries.

By Molecule Type

By Products

By Services

Contact Us

Copyright © Protheragen. All rights reserves.