AdipoUpX™ Human NFKB1 MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human NFKB1 MMLV Particle (Overexpression) is a ready-to-use retroviral vector particle professionally engineered for the stable overexpression of the human NFKB1 gene. As a central mediator of inflammatory signaling, its stable expression facilitates in-depth research into chronic low-grade inflammation in obese adipose tissue. The MMLV system ensures long-term expression in dividing cell populations for consistent signaling studies. All viral products undergo comprehensive quality control, including titer and mycoplasma testing, to ensure experimental repeatability.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: NFKB1

Full Name: Nuclear factor kappa B subunit 1

Gene Symbol: KBF1; EBP-1; NF-kB; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1; NF-kappabeta

Gene ID: 4790

RefSeq ID-1: NP_001158884.1

RefSeq ID-2: NM_001165412.2

Summary: NFKB1 encodes a core component of the NF-κB transcriptional complex that orchestrates inflammatory and stress-responsive gene expression. Chronic activation of NF-κB signaling contributes to low-grade inflammation characteristic of obesity and insulin resistance, linking NFKB1 to metabolic disease pathogenesis. Multiple isoforms are generated through alternative processing.

AdipoUpX™ Human NFKB1 MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

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