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AdipoUpX™ Human KCNJ5 AAV Particle (Overexpression)
Cat. No.:
V1225XX349
Species:
Human
Target Gene:
KCNJ5
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX349-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX349-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX349-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX349-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX349-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX349-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX349-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX349-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX349-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX349-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human KCNJ5 AAV Particle (Overexpression) is a ready-to-use viral particle product that achieves stable and efficient expression of the human KCNJ5 gene through an optimized strong promoter. It is an ideal tool for studying potassium channel involvement in aldosterone secretion and metabolic syndrome phenotypes. All products undergo rigorous internal quality control to ensure reliability. Our customizable platform also allows for flexible selection of serotypes for precise targeted delivery and tracking.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
KCNJ5
Full Name:
Potassium inwardly rectifying channel subfamily J member 5
Gene Symbol:
CIR; GIRK4; KATP1; LQT13; KIR3.4
Gene ID:
3762
RefSeq ID-1:
NP_000881.3
RefSeq ID-2:
NM_000890.3
Summary:
KCNJ5 produces an inward-rectifier potassium channel subunit that is regulated by G-proteins. This channel helps maintain the electrical gradient of the cell by allowing potassium to flow inward. Mutations in KCNJ5 are strongly associated with aldosterone-producing adenomas, which disrupt the hormonal balance of minerals and can impact blood pressure and metabolic stability.
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