AdipoUpX™ Human ITGAM MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human ITGAM MSCV Particle (Overexpression) provides stable overexpression of the human ITGAM gene, which encodes CD11b, a key integrin involved in immune cell activation and inflammation. Obesity is closely linked to chronic low-grade inflammation, making ITGAM a relevant target for metabolic–immune interaction studies. The MSCV retroviral system enables durable gene expression in hematopoietic stem cells, stem cells, and other mammalian models. Full quality control testing ensures experimental reliability and biosafety.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: ITGAM

Full Name: Integrin subunit alpha M

Gene Symbol: CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6

Gene ID: 3684

RefSeq ID-1: NP_000623.2

RefSeq ID-2: NM_000632.4

Summary: ITGAM encodes the αM subunit of the β2 integrin complex, forming the immune receptor Mac-1 on leukocytes. This integrin mediates adhesion, migration, and phagocytosis during immune responses. Through its role in immune cell recruitment and activation, ITGAM contributes to adipose tissue inflammation, a key driver of obesity-related insulin resistance. Multiple transcript variants have been described.

AdipoUpX™ Human ITGAM MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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