Products
- Anti-Obesity Compound Library
- GPCR/G Protein-Targeted Compounds
- Immunology/Inflammation-Targeted Compounds
- JAK/STAT-Targeted Compounds
- MAPK-Targeted Compounds
- Membrane Transporter/Ion Channel-Targeted Compounds
- Metabolism-Targeted Compounds
- NF-κB-Targeted Compounds
- Microbiology/Virology-Targeted Compounds
- Neuronal Signaling-Targeted Compounds
- PI3K/Akt/mTOR-Targeted Compounds
- Oxidation-reduction-Targeted Compounds
- Proteases/Proteasome-Targeted Compounds
- Stem Cells/Wnt-Targeted Compounds
- Tyrosine Kinase/Adaptors-Targeted Compounds
- Ubiquitin-Targeted Compounds
Online Inquiry
AdipoUpX™ Human INSR AAV Particle (Overexpression)
Cat. No.:
V1225XX232
Species:
Human
Target Gene:
INSR
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
Add to basket
| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX232-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX232-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX232-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX232-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX232-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX232-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX232-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX232-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX232-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX232-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human INSR AAV Particle (Overexpression) is a ready-to-use, high-titer AAV product that ensures efficient and stable expression of the human INSR gene. Specifically designed for rapid validation of the insulin receptor's role in glucose transport and AKT signaling, it serves as a reliable tool for accelerating insulin sensitivity research. Our customizable platform allows flexible selection of serotypes and fluorescent labels, and all products undergo rigorous internal quality control for safety and reproducibility.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
INSR
Full Name:
Insulin receptor
Gene Symbol:
HHF5; CD220
Gene ID:
3643
RefSeq ID-1:
NP_000199.2
RefSeq ID-2:
NM_000208.4
Summary:
INSR codes for the insulin receptor, a member of the receptor tyrosine kinase family. This receptor is synthesized as a preproprotein that is cleaved and assembled into a functional heterotetrameric complex on the cell surface. Upon binding to insulin, the receptor initiates the canonical insulin signaling pathway, which is indispensable for regulating glucose homeostasis, nutrient storage, and metabolic fuel utilization in tissues like muscle and adipose tissue. Mutations in INSR cause a spectrum of severe inherited insulin resistance syndromes, including Donohue syndrome and Rabson-Mendenhall syndrome, highlighting the gene's indispensable role in human metabolic health.
Related Products
-
AdipoUpX™ Human TNMD AAV Particle (Overexpression)
-
LipoKnoxa™ Human ADRB2 shRNA AAV Particle (Silencing)
-
AdipoUpX™ Human KIDINS220 AAV Particle (Overexpression)
-
LipoKnoxa™ Human LEPR shRNA AAV Particle (Silencing)
-
AdipoUpX™ Human MCHR1 AAV Particle (Overexpression)
-
AdipoUpX™ Human DYRK1B AAV Particle (Overexpression)