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AdipoUpX™ Human DYRK1B AAV Particle (Overexpression)
Cat. No.:
V1225XX220
Species:
Human
Target Gene:
DYRK1B
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX220-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX220-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX220-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX220-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX220-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX220-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX220-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX220-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX220-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX220-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human DYRK1B AAV Particle (Overexpression) is engineered for stable functional validation of the human DYRK1B gene. As a kinase implicated in abdominal obesity and metabolic syndrome, it facilitates systematic investigation into adipogenesis and glucose metabolism. Clients can freely select from multiple AAV serotypes and promoters for precise targeting. Comprehensive quality control is also performed on all viral products, ensuring the highest standards of safety and reproducibility.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
DYRK1B
Full Name:
Dual specificity tyrosine phosphorylation regulated kinase 1B
Gene Symbol:
MIRK; AOMS3
Gene ID:
9149
RefSeq ID-1:
NP_004705.1
RefSeq ID-2:
NM_004714.3
Summary:
DYRK1B encodes a nuclear protein kinase involved in cell cycle regulation. The protein’s expression may be altered in certain tumors, reflecting a role in cell proliferation control. Pathogenic variants in DYRK1B have been identified as a cause of abdominal obesity–metabolic syndrome 3, linking it to metabolic dysfunction. Alternative splicing generates multiple transcript variants, supporting functional diversity of this kinase in cellular signaling and metabolism.
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