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AdipoUpX™ Human INS AAV Particle (Overexpression)
Cat. No.:
V1225XX203
Species:
Human
Target Gene:
INS
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
Add to basket
| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX203-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX203-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX203-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX203-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX203-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX203-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX203-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX203-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX203-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX203-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human INS AAV Particle (Overexpression) has undergone comprehensive quality control and efficiently expresses the human INS gene, the primary regulator of anabolic metabolism and glucose uptake. This makes it an ideal tool for studying insulin biosynthesis, secretion, and its systemic impact on energy homeostasis. Our platform offers highly customizable services, allowing clients to freely select from multiple serotypes and cell-specific promoters for precise targeting, with guaranteed safety through comprehensive QC screening.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
INS
Full Name:
Insulin
Gene Symbol:
IDDM; ILPR; IRDN; IDDM1; IDDM2; PNDM4; MODY10
Gene ID:
3630
RefSeq ID-1:
NP_000198.1
RefSeq ID-2:
NM_000207.3
Summary:
The INS gene encodes insulin, a key peptide hormone essential for the regulation of glucose and lipid metabolism. Following translation, preproinsulin is processed to proinsulin and subsequently cleaved into mature insulin, composed of A and B chains linked by disulfide bonds, along with the C-peptide. Insulin binding to its receptor triggers glucose uptake and downstream metabolic signaling. Variants in the INS gene have been associated with a wide spectrum of metabolic disorders, including neonatal diabetes, maturity-onset diabetes of the young, and hyperproinsulinemia. INS also overlaps with the read-through gene INS-IGF2, reflecting complex transcriptional regulation at this locus.
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