AdipoUpX™ Human IL10 MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human IL10 MMLV Particle (Overexpression) is a ready-to-use retroviral vector particle professionally engineered for the stable overexpression of the human IL10 gene. This anti-inflammatory cytokine is a key target for studying the resolution of adipose tissue inflammation and the maintenance of insulin sensitivity. MMLV-mediated integration into dividing host cells ensures long-lasting expression for high-fidelity functional studies. All viral products undergo rigorous internal quality control to ensure safety and data reproducibility.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: IL10

Full Name: Interleukin 10

Gene Symbol: CSIF; TGIF; GVHDS; IL-10; IL10A

Gene ID: 3586

RefSeq ID-1: NP_000563.1

RefSeq ID-2: NM_000572.3

Summary: IL10 encodes a potent anti-inflammatory cytokine produced by monocytes and lymphocytes that provides essential immunoregulation. It functions by down-regulating the expression of Th1 cytokines and MHC class II antigens on macrophages, while simultaneously promoting B cell survival. By inhibiting NF-kappa B activity and modulating the JAK-STAT pathway, IL-10 helps maintain a healthy immune environment, particularly within the intestinal tract.

AdipoUpX™ Human IL10 MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

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