AdipoUpX™ Human GFRAL MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human GFRAL MMLV Particle (Overexpression) is a ready-to-use retroviral vector particle professionally engineered for the stable overexpression of the human GFRAL gene. As the specific hindbrain receptor for GDF15, it is a primary focus for research into nausea-mediated appetite suppression and weight loss. MMLV-mediated integration provides a reliable tool for establishing stable cell lines for functional signaling validation. Rigorous quality control, including titer and mycoplasma testing, ensures the repeatability and safety of your metabolic research.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: GFRAL

Full Name: GDNF family receptor alpha like

Gene Symbol: GRAL; UNQ9356; C6orf144; bA360D14.1

Gene ID: 389400

RefSeq ID-1: NP_997293.2

RefSeq ID-2: NM_207410.2

Summary: GFRAL encodes the receptor for growth differentiation factor 15 (GDF15), forming a signaling pathway that suppresses appetite and reduces body weight. Activation of the GDF15–GFRAL axis influences MAPK and PI3K–AKT signaling, positioning GFRAL as a key regulator of energy intake and body weight homeostasis.

AdipoUpX™ Human GFRAL MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

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